A limitation of our research is the white race of our population, such that our results might not be applicable to other races or ethnic groupings.34 Another limitation is our 7.2-year follow-up period, which is definitely shorter than the 10-year period for which the Framingham risk score is definitely calculated.35 This discrepancy may have reduced the entire power of our observations. In addition, we relied on a single skilled and supervised sonographer to acquire high-quality measurements during carotid-artery ultrasonography, but this may affect the implementation of our findings in primary avoidance, since we believe that the sonographer’s judgment and encounter affect the evaluation for plaque in the internal carotid artery.10 The 75th-%ile threshold can be followed in the report of the Screening for CORONARY ATTACK Prevention and Education Task Force,12 and its use happens to be reimbursed in one state.5 mm, offers modest incremental value to the Framingham risk score in predicting cardiovascular events.This margin is certainly in keeping with that in other trials in this human population.5 percent. Security and Efficacy analyses had been performed in the intention-to-treat population and protection population, respectively; all participants were included by both populations who have underwent randomization and received at least one dose of study drug. Both populations were identical in this study. A sensitivity analysis of the primary end stage was performed in the per-process population, which comprised the intention-to-treat population with the exclusion of participants with a protocol deviation that met prespecified criteria .
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