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However, the incidence of the primary end point in the bivalirudin group was lower than predicted. Although this favors the efficacy and safety of bivalirudin, it reduced to 73 percent the real power of the analysis to detect a notable difference between the two treatment groups; the reduced power can be a limitation of the study. Furthermore, the results of this trial is probably not generalizable to individuals in whom either a smaller dosage or no loading dosage of clopidogrel is definitely administered, newer adenosine-diphosphate receptor antagonists are used, or PCI is conducted through a radial artery. Myocardial infarction and the resultant elevation of biomarkers at research entry make it challenging to detect myocardial injury after the procedure.