Kathryn Maitland.

Secondary end factors were mortality at four weeks, neurologic sequelae at 4 and 24 several weeks, episodes of hypotensive shock within 48 hours after randomization, and adverse events potentially related to liquid resuscitation . An end-stage review committee, whose members were unaware of the treatment assignments, reviewed all deaths, neurologic sequelae, and adverse occasions. Randomization Randomization was performed in permuted blocks of random sizes and was stratified according to clinical center.Children often result in the er after accidentally ingesting their parent’s prescriptions. How did we let this happen? Cunningham believes the prescription opioid epidemic was born from just how we look at and treat pain in the U.S. She explains that twenty years ago there was a movement to ensure that discomfort was adequately treated. ‘Discomfort became the fifth vital sign,’ she says. As it became routine to rank pain on a sliding level, doctors experienced compelled to offer stronger drugs to treat it, and wrote more and more prescriptions.