AMPK might regulate epigenetic mechanism: Research AMP-activated protein kinase.

These initial observations were made in tissue-tradition cells and the group is now attempting to confirm them in animal models. Related StoriesBetalin launches brand-new EMP technology that could transform diabetes treatmentMD Anderson research reveals why chemotherapy drugs not effective for many pancreatic tumor patientsUnderstanding how schizophrenia impacts workings of the brainAMPK’s main function is to feeling cell tension. In this study, cells had been stressed with ultraviolet radiation and low degrees of glucose, a common source of cell energy. In the sequence of occasions after stress, AMPK accumulates the cell-stress signal and travels to the nucleus to bind to the important tumor suppressor p53 protein. Therefore, causes a phosphate to be added to a histone close to the p21 gene, which turns the gene on.Understanding their origins and how they activate NKT cells to trigger asthma may reveal fresh biological pathways that can be targeted by medicines, the researchers say. In addition to looking for these antigens, Umetsu, Akbari and colleagues intend to look at milder asthma and extend their studies to kids to see if NKT cells play an identical role. They’ll also seek means of switching off or counteracting NKT cells, which could be progressed into new medicines. Corticosteroids, which target Th2 cells and various other inflammatory cells, reduce inflammation but appear to have little influence on NKT cells, Umetsu says.