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Yu, M.D., Ph.D., and Christopher A. Walsh, M.D., Ph.D.: Somatic Mutations in Cerebral Cortical Malformations Somatic mutation, a postzygotic event, leads to several populations of cells with specific genotypes within an organism, despite development from a single fertilized egg. A notch reduced the hierarchy of severity will be the somatic mutations within individuals with tuberous sclerosis, the double-cortex syndrome, periventricular nodular heterotopia, and bilateral megalencephalic disorders; these persons typically have milder presentations of disease than do those who carry the mutation in their germline.1,8,9 The broader relevance of somatic mutations to other neurologic conditions, such as for example epilepsy and autism in persons without structural brain malformations, is not known.